Supratentorial ependymoma in childhood: more than just RELA or YAP

Childhood Intracranial Ependymoma Presenting as Cystic Supratentorial Brain Tumour

Approximately 50% of all childhood brain tumours arise in the infratentorial fossa and the most common tumours in this region of the brain are cerebellar astrocytomas, medulloblastomas, ependymomas, and brainstem gliomas [1]. Conversely in the suratentorial fossa, up to 20% of childhood tumours arise in the suprasellar region with craniopharyngiomas, visual pathway gliomas, and germinomas as th...

Recurrence in supratentorial anaplastic ependymoma.

AIM To study the outcome and recurrence in supratentorial anaplastic ependymoma. METHODS Sixteen cases of supratentorial anaplastic ependymoma were reviewed. The average age of presentation was 8.2 years ranging from 1 to 16 years of age. The mean duration between the onset of first symptoms to time of presentation was 4.2 months. Follow-up ranged from 5 to 58 months with a mean of 16.8 month...

Supratentorial ectopic ependymoma.

BACKGROUND Ependymomas usually arise from the ventricular surface. METHODS We report an 11-year-old female who presented with a supratentorial ectopic ependymoma. RESULTS The patient presented with a two-month-history of progressive headache, nausea and vomiting. Examination revealed papilledema, horizontal nystagmus, diplopia on upward gaze, and right pronator drift. CT scan showed an enha...

Aggressive Supratentorial Ependymoma, RELA Fusion-Positive with Extracranial Metastasis: A Case Report

Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome. For supratentorial (ST) ependymomas, RELA fusion-positive ependymomas show a more aggressive behavior than YAP1 fusion-positive ependymomas. Extracranial metastases of...

More than just vanilla.